Author/Authors :
Irfan, S. Aga Khan University - Department of Pathology Microbiology, Pakistan , Ahmad, A. Aga Khan University - Department of Pathology Microbiology, Pakistan , Guhar, D. Aga Khan University - Department of Pathology Microbiology, Pakistan , Khan, E. Aga Khan University - Department of Pathology Microbiology, Pakistan , Malik, F. Aga Khan University - Department of Pathology Microbiology, Pakistan , Mahmood, S. Aga Khan University - Department of Pathology Microbiology, Pakistan , Zafar, A. Aga Khan University - Department of Pathology Microbiology, Pakistan
Abstract :
Fluoroquinolone and macrolide antibiotics are generally considered as first-line drugs for the treatment of severe campylobacteriosis. This study was conducted to analyse the trend of erythromycin and ofloxacin resistance among Campylobacter spp. isolated from stool specimens over a period of 15 years (1992– 2007) at The Aga Khan University clinical laboratory in Karachi, Pakistan. A total of 83 396 stool specimens were processed, with a 14% isolation rate for enteric pathogens. The isolation rate of Campylobacter spp. was low during 1992–93 (6%–13%), peaked in 1996 (46%), then ranged from 20% to 40%. We report a rising trend in ofloxacin resistance, re-emergence of erythromycin resistance and indications of co-resistance to both drugs in clinical isolates of Campylobacter spp.
