Title of article
Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening
Author/Authors
Alafeefy, Ahmed M. AlKharj University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , El-Azab, Adel S. King Saud University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , Mohamed, Menshawy A. AlKharj University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , Bakhat, Mohamed Afroz AlKharj University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , Abdel-Hamid, S. G. AlKharj University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia
From page
319
To page
325
Abstract
A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c] quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.
Keywords
Synthesis , 6 , Iodo , 2 , thienylquinazolin , 4(3H) , one , Antimicrobial screening
Journal title
Journal of Saudi Chemical Society
Journal title
Journal of Saudi Chemical Society
Record number
2641984
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