Author/Authors :
Elbadawi, N.E.E. University of Kassala - Department of Biochemistry, Sudan , Mohamed, M.I. University of National Ribat - Department of Biochemistry, Sudan , Dawod, O.Y. University of Kassala - Department of Physiology, Sudan , Ali, K.E. International Africa University - Department of Biochemistry, Sudan , Daoud, O.H. Alzaeem Alazhari University - Department of Paediatrics, Sudan , Ali, E.M. University of Khartoum - Department of Medicine, Sudan , Ahmed, E.G.E. University of Kassala - Department of Medicine, Sudan , Mohamed, A.E. University of Gezira - Faculty of Medicine - Department of Biochemistry, Sudan
Abstract :
To determine if quinine has a metabolic effect during treatment of severe or complicated malaria, we studied its effects on plasma glucose and plasma insulin levels in 150 pregnant women with malaria referred to Madani maternity teaching hospital, Gezira state and 50 healthy pregnant controls. Levels were determined at baseline (day 0) before the start of quinine treatment, after 2 days of treatment (2 hours after the 4th dose) and after 7 days of treatment (day 8). There was a statistically significant increase in plasma insulin concentrations during the quinine infusion and fall in plasma glucose concentration (P 0.001). Quinine administered at the recommended dose and rate can disrupt plasma glucose homeostasis although it is still the drug of choice for severe and complicated malaria in Sudan.
