Author/Authors :
Noorbakhsh, S. tehran university of medical sciences tums - Research Centre of Paediatric Infectious Diseases, تهران, ايران , Farhadi, M. tehran university of medical sciences tums - Ear, Nose and Throat Diseases Research Centre, تهران, ايران , Daneshi, A. tehran university of medical sciences tums - Ear, Nose and Throat Diseases Research Centre, تهران, ايران , Mohamadi, S. tehran university of medical sciences tums - Ear, Nose and Throat Diseases Research Centre, تهران, ايران , Tabatabaei, A. tehran university of medical sciences tums - Research Centre of Paediatric Infectious Diseases, تهران, ايران
Abstract :
The etiology of sensorineural hearing loss (SNHL) in children may be viral. This cross-sectional study aimed to determine the role of viral infectious agents in children with idiopathic SNHL. Of 119 children with SNHL aged 3–168 months undergoing cochlear implant surgery at a hospital in Tehran, no cause could be established in 18 cases (15.1%). Cytomegalovirus (CMV) and herpes simplex virus (HSV) active infections (detected by DNA-PCR, confirmed by serology) were found in the perilymphatic fluid of 16.7% (3/18) cases of idiopathic SNHL. Serology was performed on blood samples from 11 of these cases: specific antibodies against CMV, Toxoplasma spp., HSV and rubella were determined in all cases; acute T. gondii infection was detected in 7 cases and rubella IgG was found in only 1 case. Neonatal screening for CMV, HSV and T. gondii may be helpful in the Islamic Republic of Iran.
