Title of article
Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt
Author/Authors
Anwar, M.M. University of Alexandria - Medical Research Institute - Department of Experimental and Clinical Surgery, Egypt , Youssef, A.I. University of Alexandria - Medical Research Institute - Department of Applied Medical Chemistry, Egypt , Sheta, M.I. University of Alexandria - Medical Research Institute - Department of Pathology, Egypt , Zaki, A. University of Alexandria - Medical Research Institute - Department ofMedical Informatics and Medical Statistics, Egypt , Bernaba, N.R. University of Alexandria - Medical Research Institute - Department of Applied Medical Chemistry, Egypt , El-Toukhi, M.A. University of Alexandria - Medical Research Institute - Department of Applied Medical Chemistry, Egypt
From page
501
To page
507
Abstract
The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer (serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection) in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pyloriassociated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity (100%). We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 μg/mL is essential.
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2642800
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