Author/Authors :
Rasool, Mahmood King Abdulaziz University - Center of Excellence in Genomic Medicine Research (CEGMR), Saudi Arabia , Khan, Saima Rubab University of Lahore - Institute of molecular biology and biotechnology, Pakistan , Malik, Arif University of Lahore - Institute of molecular biology and biotechnology, Pakistan , Khan, Khalid Mahmood Fatima Jinaah Medical College - Sir Ganga Ram Hospital, Pakistan , Zahid, Sara University of Lahore - Institute of molecular biology and biotechnology, Pakistan , Manan, Abdul University of Lahore - Institute of molecular biology and biotechnology, Pakistan , Qazi, Mahmood Husain University of Lahore - Centre for Research in Molecular Medicine, Pakistan , Naseer, Muhammad Imran King Abdulaziz University - Center of Excellence in Genomic Medicine Research (CEGMR), Saudi Arabia
Abstract :
Objective: Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods: Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. Results: Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion: ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.
Keywords :
Neoplastic , Squamous Cell Carcinoma , Lipid peroxidation , MDA
