A Biphasic Release System of Lornoxicam Based on “Tablets in Capsule” Device

The aim of the present investigation is to obtain a programmed drug delivery from a novel system containing a fast release and prolonged release tablet (PRT) placed into a capsule to achieve the biphasic release pattern of lornoxicam. Fast release tablets (FRT) with 3.25 mg were prepared with different diluents and varying concentrations of disintegrant and binders. Hydrogenated castor oil and hydrogenated vegetable oil are used tomodulate drug release for the development of PRT with a 12.25 mg dose calculated as a zero-order principle.The compressed tablets were evaluated for various physicochemical parameters like hardness, friability, drugcontent uniformity, weight variation and in-vitro drug release studies. The optimized FRT and PRT tablets wereplaced in the size 2 capsule to attain biphasic release in which the immediate rapid release was obtained by theFRT followed by slow release from the PRT for 24 hours. The optimized ‘tablet in capsule’ (TCHV) (containing3%w/w of HVO) followed first-order release with a Non-Fickian diffusion mechanism. FT-IR studies revealedno interaction between the drug and polymers. There were no marketed dosage forms of lornoxicam withbiphasic release; hence, the present study indicated the applicability of the ‘tablets in capsule’ technique in thedesign of biphasic release systems of lornoxicam