Title of article :
Epoxidationof Ferutinin by Different Fungi and Antibacterial Activity of its Metabolite
Author/Authors :
Choudhary, M. Iqbal University of Karachi - H E J Research Institute of Chemistry / International Center for Chemical and Biological Sciences, Pakistan , Choudhary, M. Iqbal King Saud University - College of Science - Department of Chemistry, Saudi Arabia , Mohammad, Mohammad Yasin University of Karachi - H E J Research Institute of Chemistry / International Center for Chemical and Biological Sciences, Pakistan , Musharraf, Syed Ghulam University of Karachi - H E J Research Institute of Chemistry / International Center for Chemical and Biological Sciences, Pakistan , ur-Rahman, Atta University of Karachi - H E J Research Institute of Chemistry / International Center for Chemical and Biological Sciences, Pakistan
Abstract :
Structural transformation of the sesquiterpene ester, ferutinin (1), by suspended fungal cultures of Aspergillus niger, Rhizopus stolonifer, and Fusarium lini, resulted in the formation of a metabolite. This metabolite was identified as ferutinin α-epoxide (2), by different spectroscopic techniques. Metabolite 2 showed a good antibacterial activity against Staphylococcus aureuscompared to ferutinin (1) Keywords: Sesquiterpene ester, ferutinin, fungal transformation, Aspergillus niger, Rhizopus stolonifer,Fusarium lini, ferutinin α-epoxide, epoxidation, Staphylococcus aureus, antibacterial activity.
Journal title :
Jordan Journal of Pharmaceutical Sciences
Journal title :
Jordan Journal of Pharmaceutical Sciences
