Title of article :
STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE
Author/Authors :
Ali, Perry H. University of Baghdad - College of Sciences for Women - Department of Biochemistry Chemistry, Iraq , Husain, Jinan University of Baghdad - College of Sciences for Women - Department of Biochemistry Chemistry, Iraq , Hashim, Iman University of Baghdad - College of Sciences for Women - Department of Biochemistry Chemistry, Iraq
Abstract :
We have studied for the first time in Iraq, the effect of aspegic and paracetamol on the activity of creatine kinase in the sera of 25 premenopausal health women our results revealed that in the presences of increasing concentrations of aspegic and paracetamol the activity of creatine kinase is inhibited and the inhibition is concentration dependant and independent respectively. The kinetic parameter of creatine kinase was measured (Vmax= 133.3.00 IU/L, Km=(2.13 ± 0.2 mM).Aspegic act as reversible competitive inhibitor for CK(150 ± 3.3 IU/L , Km= 2.4± 0.4mM) and paracetamol act as reversible uncompetitive inhibitor for creatine kinase (87.72± 2.1 IU/L, Km=2.02 ± 0.33 Mm).
Journal title :
Al-Nahrain Journal Of Science
Journal title :
Al-Nahrain Journal Of Science
