Title of article :
Application and evaluation of a molecular approach for detection of the schistosomicidal effect of Mirazid® (myrrh) in the murine model
Author/Authors :
Lotfy, Wael M. Alexandria University - Medical Research Institute - Parasitology Department, Egypt , Nageh, Aly M. Alexandria University - Medical Research Institute - Department of Applied Medical Chemistry, Egypt , Hussein, Neveen A. Alexandria University - Medical Research Institute - Department of Applied Medical Chemistry, Egypt , Hassan, Ashraf A. Alexandria University - Medical Research Institute - Department of Applied Medical Chemistry, Egypt , Hassan, Ashraf A. Jazan University - Faculty of Health Sciences - Department of Laboratory Sciences, Saudi Arabia
Abstract :
The conventional PCR technique was used for studying the schistosomicidal effect of Mirazid® in the murine model. Results of the molecular study were compared with the parasitological results (ova and worm count). The used PCR technique was more sensitive than the Kato-Katz thick smears. Mirazid® showed some schistosomicidal effects against murine Schistosoma mansoni. However, it was not efficient enough to cure any of the studied mice.
Keywords :
Mirazid , Murine , Schistosoma mansoni , Antischistosomal , PCR , Diagnosis , Treatment
Journal title :
Journal of Advanced Research
Journal title :
Journal of Advanced Research
