Title of article
SUBCHRONIC TREATMENT WITH MERCURIC CHLORIDE SUPPRESSES IMMUNE RESPONSE, ELICITS BEHAVIORAL DEFICITS AND INCREASES BRAIN SEROTONIN AND DOPAMINE METABOLISM IN RATS
Author/Authors
NAZ, HAJRA University of Karachi - Department of Biochemistry, Neurochemistry, Biochemical Neuropharmacology Unit, Pakistan , BAIG, NADEEM Karachi Medical Dental College - Department of Anatomy,Basic Medical Sciences, Pakistan , HAIDER, SAIDA University of Karachi - Department of Biochemistry, Neurochemistry, Biochemical Neuropharmacology Unit, Pakistan , HALEEM, DARAKHSHAN J. University of Karachi - Department of Biochemistry, Neurochemistry, Biochemical Neuropharmacology Unit, Pakistan
From page
7
To page
11
Abstract
In view of the neurotoxic effects of mercuric chloride the following study was designed to explore its effects on brain serotonin and dopamine metabolism. Mercuric chloride injected at a dose of 1 mg/ml/kg increased locomotor activity, decreased latency to move, corner sittings and food intake. A decrease of 33% of immune response was observed in mercuric chloride treated rats as evident from anti nuclear antibody (ANA) positive test. Neurochemical analysis revealed that mercuric chloride administration increased brain tryptophan concentrations 5-Hydroxyindoleacetic acid (5-HIAA) and dihydroxyphenyl acetic acid, while 5- Hydroxytryptamine (5-HT) and Dopamine (DA) were decreased. The results also showed an increase in brain 5-HT and DA turnover rate in mercuric chloride injected rats. These increases in 5-HT and DA metabolism suggest that mercuric chloride may tend to contribute to anorexia and hyperactivity induced in drug administered rats.
Keywords
Mercuric chloride , ANA , 5 , HT metabolism , DA metabolism
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2646748
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