Thermodynamic Studies for the Interaction of Some Anticoagulant Drugs with Albumin

Fluorescence spectroscopy in combination with UV- vis absorption spectroscopy was employed to investigate the binding of some important anticoagulant drugs warfarin, heparin and aspirin to human serum albumin under physiological conditions. Scatchard equation provide a measure of the binding affinity between these three drugs individually and albumin. The results of thermodynamic parameters ΔG, ΔH, and ΔS at three different temperatures indicate that the hydrophobic interaction plays a major role for the interaction between each of these drugs and albumin.