Title of article :
PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE
Author/Authors :
BASHIR, SAJID University of Balochistan - Department of Pharmacy, Pakistan , JAMSHAID, MOHAMMAD University of Punjab - University College of Pharmacy, Pakistan , AHMAD, BASHIR University of Punjab - University College of Pharmacy, Pakistan , IQBAL, JAVEID University of Balochistan - Department of Pharmacy, Pakistan
Abstract :
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC (0-t) and AUC (0-inf) were significantly different between normal and dehydrated rabbits (P 0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
Keywords :
Pharmacokinetics , ciprofloxacin , plasma concentration , dehydrated rabbits
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
