Author/Authors :
RAHMAN, BYTUL M. University of Rajshahi - Department of Pharmacy, Bangladesh , IBNE WAHED, MIR IMAM University of Rajshahi - Department of Pharmacy, Bangladesh , KHONDKAR, PROMA University of Rajshahi - Department of Pharmacy, Bangladesh , AHMED, MARUF University of Rajshahi - Department of Pharmacy, Bangladesh , ISLAM, ROBIUL University of Rajshahi - Department of Pharmacy, Bangladesh , BARMAN, RANJAN K Square Pharmaceuticals Ltd. - Quality Compliances Department, Bangladesh , ISLAM, M. ANWAR UL University of Rajshahi - Department of Pharmacy, Bangladesh
Abstract :
High shear wet granulation is a preferred manufacturing method of tablets. It allowed for rapid production of compressible granulations. The resultant granulation characteristics depend on a combination of formulation properties and processing parameters. Fully pregelatinized starches are currently being used as binders in wet granulated formulations. But due to the gelatinization, much of the disintegration properties are lost. Partially pregelatinized starches (Starch 1500) have a mixture of properties of both native and fully gelatinized starches; made them useful as both a binder and a disintegrant in wet granulated formulations. Starch 1500 performed as an excellent binder producing a granulation that was compressible and produced Lamivudine tablets of improved hardness and friability compared with those prepared with povidone. The formulation of Lamivudine tablets with Starch 1500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. High shear wet granulation is also well suited for the use of partially pregelatinized starches.
Keywords :
Starch 1500 , binder , disintegrant , lamivudine tablets , wet granulation
