Author/Authors :
ALI, RUBAIYA Bangabandhu Sheikh Mujib Medical University - Department of Dermatology, Bangladesh , AHSAN, MOHAMMAD SHAMSUL Bangabandhu Sheikh Mujib Medical University - Department of Psychiatry, Bangladesh , AZAD, MOHAMMAD ABUL KALAM University of Dhaka - Department of Pharmaceutical Technology, Bangladesh , ULLAH, MD. ASHIK University of Dhaka - Department of Clinical Pharmacy and Pharmacology, Bangladesh , BARI, WASIMUL University of Dhaka - Department of Statistics, Bangladesh , ISLAM, SHEIKH NAZRUL University of Dhaka - Institute of Nutrition and Food Sciences, Bangladesh , YEASMIN, SABINA University of Dhaka - Department of Genetic Engineering and Biotechnology, Bangladesh , HASNAT, ABUL University of Dhaka - Department of Clinical Pharmacy and Pharmacology, Bangladesh
Abstract :
In the present study, the serum immunoglobulin profiles of vitiligo patients were compared with that of cohort control and evaluated the correlation between immunoglobulin level with their socioeconomic factors and nutritional status. Thirty vitiligo patients were recruited randomly from the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh for this study. Thirty healthy individuals as control group matched by age, sex, education and socioeconomic factors to the patient group were selected. Serum immunoglobulin concentrations were determined by turbidimetry method using immunoglobulin kit. The concentration of IgG and IgA decreased significantly (P 0.05), but the change of IgM was not significant. Socioeconomic data revealed that most of the patients were young and female. Moreover statistical analysis revealed that there was significant correlation between immunoglobulin (IgG and IgA only) concentrations and BMI and number of depigmented patches with IgG concentrations. Finally it can be concluded that the change of serum immunoglobulin concentration in vitiligo patients could be due to the disease condition as pathomechanism suggested the aberrations in cellular immunity. But study with larger number of population is required for further evaluation of the relationship between the immune response and disease state to confirm these findings.
