Title of article :
ANTIDIARRHOEAL AND ANTIULCER ACTIVITIES OF HIPPOCRATEA AFRICANA ROOT EXTRACT
Author/Authors :
OKOKON, JUDE EFIOM University of Uyo - Faculty of Pharmacy - Department of Pharmacology and Toxicology, Nigeria , AKPAN, HENRY DAN University of Uyo - Faculty of Basic Medical Sciences, College of Health Sciences - Department of Biochemistry, Nigeria , UMOH, EMEM EKPO University of Uyo - Faculty of Pharmacy - Department of Pharmacology and Toxicology, Nigeria , EKAIDEM, ITEMOBONG SUNDAY University of Uyo Teaching Hospital - Department of Chemical Pathology, Nigeria
Abstract :
The effect of ethanol root extract of H. africana on experimentally induced diarrhoea and ulcer was studied in rodents. The extract (200 – 600mg/kg) considerably inhibited castor oil induced diarrhoea, small intestine transit time and castor oil induced fluid accumulation as well as indomethacin and ethanol induced ulcer models. The effect of the extract in these models was comparable to the various standard drugs used. The root extract of H. africana has antidiarrhoeal and antiulcer properties which justify its uses in ethnomedicine.
Keywords :
Hippocratea africana , antidiarrhoea , antiulcer , rodents.
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
