Author/Authors :
Curcio, Sergio Augusto Fudaba Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil , Stefan, Luciana Francine Bocchi Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil , Randi, Bruno Azevedo Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil , Dias, Marco Antonio Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil , Silva, Rodrigo Eduardo da Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil , Caldeira, Eduardo José Faculdade de Medicina de Jundiaí (FMJ) - Faculty of Medicine of Jundiaí - Tissue Morphology Laboratory, Department of Morphology and Basic Pathology, Brazil
Abstract :
The objective of this study was to evaluate the salivary glands in diabetic mice, analyzing alterations in the secretory epithelium and interactions with the stromal compartment acquired during a prolonged period of treatment with Bauhinia forficata extract. Female mice were divided into two groups: Nonobese diabetic (NOD) mice treated with Bauhinia forficata (I), and NOD mice not treated with the hypoglycemic agent (II). After treatment, the salivary glands were collected for analysis by transmitted and polarized light microscopy, complemented by three-dimensional analysis of these tissues. The results showed weight loss in animals of group II and weight recovery in treated animals. Glucose levels were elevated in group II, but declined in group I. In the two groups, the salivary glands were characterized by involution of the secretory epithelium, presence of an inflammatory infiltrate and an increase of extracellular fibrillar components. It can be concluded that treatment with Bauhinia forficata reduced glucose levels and contributed to weight recovery in treated animals. However, the observation of tissue destructuring and compromised epithelial-stromal interactions, with consequent impairment of glandular function, demonstrates that Bauhinia forficata exerts an effect on the recovery of body metabolism but this improvement does not influence in the tissue recovery. Keywords: Treatment; hypoglycemic effect; diabetes mellitus; salivary glands.
Keywords :
Treatment , hypoglycemic effect , diabetes mellitus , salivary glands.
