Author/Authors :
Lee, Yang Kok Universiti Sains Malaysia - 1Centre for Drug Research (CDR), Malaysia , Lay, Lam Kit Universiti Sains Malaysia - Institute for Research in Molecular Medicine (INFORMM), Malaysia , Mahsufi, Mansor Sharif Universiti Sains Malaysia - Centre for Drug Research (CDR), Malaysia , Guan, Teoh Siang Universiti Sains Malaysia - School of Chemical Sciences, Malaysia , Elumalai, Sunderasan Rubber Research Institute of Malaysia, Malaysia , Thong, Ong Ming Universiti Sains Malaysia - Institute for Research in Molecular Medicine (INFORMM), Malaysia
Abstract :
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancerorigin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum subfractions in cancer treatment.
Keywords :
Hevea brasiliensis , B , serum , anti , cancer , breast cancer, epithelial cells.
