Author/Authors :
Akhtar, Shamim University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Arif, Muhammad University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Mushtaq, Nousheen University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Saify, Zafar Saeed University of Karachi - HEJ Research Institute of Chemistry, Pakistan , Ahmed, Ahsaan University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Haleem, Darakhshan Jabeen University of Karachi - Centre of Neuropharmacology - Department of Biochemistry, Pakistan , Akram, Arfa Federal Urdu University of Arts, Science and Technology, Pakistan
Abstract :
Study of natural products led to the development of new molecules of potential biological activity. Piperidine nucleus constitutes one of the components of various alkaloids and drugs. During the course of our project regarding the synthesis of derivatives of piperidine carboxamide to study the effects of these compounds as anti-depressive agents, some of the compounds exhibited significant effects at all three doses, through open field activity thus establishing a direct relationship between dose and locomotion. Moreover, these compounds have also shown the decreased level of 5- HT alone with increased level of dopamine as an indication of their antagonism towards 5-HT receptor.
Keywords :
Neurochemical Profile , neurotransmitters , biogenic amines , catecholamine , indolamine , antagonism , depression.
