Author/Authors :
Jamil, Muhammad Saim Hamdard University - Faculty of Eastern Medicine, Pakistan , Mahmood, Zahid Agriculture University - Department of Biochemistry, Pakistan , Saeed, Aftab Hamdard University - Faculty of Eastern Medicine, Pakistan , Jamil, Amir Agriculture University - Department of Biochemistry, Pakistan , Usmanghani, Khan Hamdard University - Faculty of Eastern Medicine, Pakistan , Asif, Hafiz Muhammad University of Poonch - Faculty of Medical Health Sciences - Department of Eastern Medicine Surgery, Pakistan , Sajjad-al-Hassan Agriculture University - Department of Biochemistry, Pakistan , Roohi, Mahira Agriculture University - Department of Biochemistry, Pakistan
Abstract :
Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation “Hepcon” to evaluate its hepatoprotective effects in drug induced hepatitis in experimental animals. The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs (NSAIDs) and carbon tetrachloride (CCl4). The herbo-mineral formulations “Hepcon” consist of Zingiber officinale, Piprum nigrum, Ammonium chloride and Arsenic trioxide (Hartal warqi). The aqueous extraction was administered to experimental animals. Thereafter their LFTs, IgG, and tissue pathology was studied. It was observed on the basis of biochemical and histopathological analysis that animals which were subjected to Hepcon became normal in 60 days whereas those as control group did not showed improvements and most of them died. It was concluded that the efficacy of Hepcon to treat liver injury caused by CCl4 and NSAIDs is very effective, and no side effects were noticed.
Keywords :
Drug induced hepatitis , efficacy , Hepcon , experimental animals
