Title of article
Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents
Author/Authors
Khan, Shagufta Aga Khan University Hospital - Medical College - Department of Biological and Biomedical Sciences, Pakistan , Abbas, Ghulam COMSATS Institute of Information Technology - Department of Pharmaceutical Sciences, Pakistan , Ahmed, Fahad Shabbir Aga Khan University Hospital - Medical College - Department of Post Graduate of Medical Education, Pakistan , Atta-ur-Rahman University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan , Dar, Ahsana University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan
From page
303
To page
307
Abstract
The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.
Keywords
Areca catechu nut , dichloromethane fraction , serotonin , dopamine , cheese effect
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2647909
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