Author/Authors :
Khan, Shagufta Aga Khan University Hospital - Medical College - Department of Biological and Biomedical Sciences, Pakistan , Abbas, Ghulam COMSATS Institute of Information Technology - Department of Pharmaceutical Sciences, Pakistan , Ahmed, Fahad Shabbir Aga Khan University Hospital - Medical College - Department of Post Graduate of Medical Education, Pakistan , Atta-ur-Rahman University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan , Dar, Ahsana University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan
Abstract :
The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.
Keywords :
Areca catechu nut , dichloromethane fraction , serotonin , dopamine , cheese effect
