Title of article :
Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats
Author/Authors :
Taj, Darakhshan University of Karachi - Biotechnology and Drug Development Laboratory, Department of Biochemistry, Pakistan , Khan, Hira University of Karachi - Biotechnology and Drug Development Laboratory, Department of Biochemistry, Pakistan , Sultana, Viqar University of Karachi - Biotechnology and Drug Development Laboratory, Department of Biochemistry, Pakistan , Ara, Jehan University of Karachi - Department of Food Science and Technology, Postharvest Technology Laboratory, Pakistan , Ehteshamul-Haque University of Karachi - Agricultural Biotechnology and Phytopathology Laboratory, Department of Botany, Pakistan
Abstract :
Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Physalis peruviana whole ripe fruit, water and ethanol extracts of fruit in normal as well as in carbon tetrachloride (CCl4) intoxicated rats. The CCl4 treated rats showed marked elevation in liver enzymes: alanine transaminse, aspratate transaminase, alkaline phosphatase, lactate dehydrogenase and other biochemical parameters: bilirubin, creatinine and urea, thus indicating liver injury. Whereas animal treated/fed with various preparations of Physalis peruviana showed significant lowering effect (p 0.05) in the elevated levels of serum markers like ALAT, ASAT, ALP, LDH, creatinine, urea and bilirubin indicating the protection against hepatic cell damage. The water extract of Physalis peruviana showed highest activity in both rat models while ripe fruit and ethanol extract showed moderate activity compared to standard drug.
Keywords :
Physalis peruviana , antihepatotoxic , CCl4 , transaminases , liver injury
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
