Author/Authors :
Khalid, Leena University of Karachi - Faculty of Pharmacy - Department of Pharmacognosy, Pakistan , Rizwani, Ghazala H University of Karachi - Faculty of Pharmacy - Department of Pharmacognosy, Pakistan , Sultana, Viqar University of Karachi - Faculty of Science - Department of Biochemistry, Pakistan , Zahid, Hina University of Karachi - Faculty of Pharmacy - Department of Pharmacognosy, Pakistan , Khursheed, Raheela University of Karachi - Faculty of Pharmacy - Department of Pharmacognosy, Pakistan , Shareef, Huma University of Karachi - Faculty of Pharmacy - Department of Pharmacognosy, Pakistan
Abstract :
The present study was undertaken to assess the antidepressant effect of crude ethanolic extract of floral part of Hibiscusrosa sinensis (HRS) at doses 100mg/kg, 250mg/kg and 500mg/kg using three parameters which are forced induced swimming test (FST), tail suspension test (TST) and open field test(OFT). Flouxetine (15mg/kg, body weight) was used as standard. Significant dose dependent decline in immobility time was observed in all the three doses in FST and TST while in case of OFT none of the dose of HRS exhibited effectual results. To determine MAO”A” and MAO”B” activity HRS extract was used and the results revealed that each dose of this plant exhibited marked effect on MAO”A”, while on MAO”B” only 250mg/kg dose was found significant.
Keywords :
Antidepressants , monoamine oxidase , forced induced swimming test , tail suspension test , open field test
