Abstract :
The study includes twenty four mice divided into two equal groups each group contain (12) animals, the first group represent the treated group which daily intraperitoealy injected with Traimecinolone at dose rate (0.5% mg/kg B.w) for 45 day, this group was subdivided according to days of killing of animals for histopathological study into three sub group (25 day group), (35 day group) and (45 day group) each group includes four animals. The second group represent control group which also subdivided to subgroups as in first group and daily injected with 0.5% normal saline. The blood was collected from the two groups for estimation of {Serum Creatinine (SC), Serum Aspartate transaminase (SAST) and Serum Alkaline Phosphatase (SALP)} after (25, 35 and 45 day) from the beginning of the study, then immediately after blood collecting four animals were killed at each periods for histopathological examination of muscle specimens. The conclusion were presence of significant differences between the concentration of SC of Traimecinolone group and control group after 35 and 45 day from the beginning of the study at (P 0.05), while the significant differences between the concentrations of SAST and SALP of Traimecinolone group and control group occur after 45 day from beginning of the study at (P 0.05), also the study revealed that the fibers of the muscle were swollen and have lost their striations and their nuclei and the muscle fibers are rounded and vary considerably in size, most relatively large(hypertrophic ) and several much smaller (atrophic), and PAS(Periodic AcidSchiff) showed deposition of glycogen and glycogen storage myopathy with multiple subsarcolemmal vacuoles
