The Prophylactic Role of Garlic Oil against deleterious Effects of sodium nitrite(Na No2) in Male Mice

In this study was investigated the Prophylactic role of garlic oil against sodium nitrite NaNO2-induced a l t e r a t i o n in physiology and biochemical parameters and oxidative status in male mice. NaNO2 sodium nitrite, a food color fixative and preservative, contributes to carcinogenesis forty 40 male mice were randomly divided into four equal groups (n= 10 as follow: 1- Control group was received standard diet without any treatment. 2-Garlic oil-treated group, was received standard diet, and given orally with garlic oil at a dose of 3 ml/kg body weight for a period of 1months, group 3- NaNO2 treated group, was received standard diet and given orally sodium nitrite at dose of 40 mg/kg body weight, group 4- NaNO2 garlic oil-treated group, was handled as animals group 3 in addition to garlic oil. T he r e s u l t s r e c o r d e d a significant increase (P 0.05) in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphates (ALP) activity, serum bilirubin, urea and creatinine c o nc e n t r a t i o n a s well as hepatic AST and ALT activity, Besides significant decrease (P 0.05) was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In addition a significant increase (P 0.05) in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. While garlic oil supplementation showed a remarkable induced a l t e r a t i o n i n b l o o d ma t t e r s a b o v e i n ma l e m i c e . The data indicate that garlic is a phyto antioxidant with powerful prophylactic properties against NaNo2 chemically-induced oxidative stress.