Title of article
Granulocyte-Colony Stimulating factor for mobilizing bone marrow stem cells in the Sub acute Stroke.How safe is the use of Granulocyte-colony stimulating factor in sub-acute stroke? Isthis stem cell trial of recovery enhancement beneficial?
Author/Authors
Nomani, Fauzia Aga Khan University Hospital - Fogarty International Center and National Institute of Neurologic Disorders and Stroke - Stroke Service and Vascular Fellowship Program, International Cerebrovascular Translational Clinical Research Training Program, Pakistan , Kamal, Ayeesha Kamran Aga Khan University Hospital - Fogarty International Center and National Institute of Neurologic Disorders and Stroke - Stroke Service and Vascular Fellowship Program, International Cerebrovascular Translational Clinical Research Training Program, Pakistan
From page
1558
To page
1559
Abstract
Efforts are being made to develop neuroprotective agents for recovery and prevention of further deterioration of brain tissues in patient with stroke.Granulocyte-colony stimulating factor (GCSF) is a glycoprotein hormone encoded by a single gene located on chromosome 17q 11-22. It functions in the regulation of granulopoiesis terminal maturation of neutrophills. It is being used for the treatment of neutropenia for the production of CD34+ haematopoietic stem cell (HSC) for bone marrow transplant patients. Neuroprotective effect of GCSF is being studied in various experimental studies but its mechanism of action is not well understood and appears to be multimodal.
Journal title
Journal of the Pakistan Medical Association (Centre) JPMA
Journal title
Journal of the Pakistan Medical Association (Centre) JPMA
Record number
2652976
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