Stage IV follicular lymphoma (Grade II) arising from skeletal muscle — a case report and literature review

This is a case report of a middle-aged male who was diagnosed to have extranodal non-Hodgkin lymphoma (NHL) appearing to arise from skeletal muscle of the left thigh. Presentation of the lymphoma with infiltration of skeletal muscle is an exceedingly rare event. We present the clinical course of the disease along with the computed tomography scan and magnetic resonance imaging findings of this case. NHL should be included as a differential diagnosis in patients (immunocompromised or non-immunodeficient) with a soft tissue involvement along with other inflammatory or neoplastic conditions.