Author/Authors :
MASOODI, MOHSEN hormozgan university of medical sciences - Department of Internal Medicine, ايران , AGHAZADEH, RAHIM shahid beheshti university of medical sciences - Research Center for Gastroenterology Liver Diseases, تهران, ايران , SOMI, MOHAMMAD HOSSEIN tabriz university of medical sciences - Tabriz Liver and Gastrointestinal Diseases Research Center, تبريز, ايران , SHAVAKHI, AHMAD isfahan university of medical sciences, اصفهان, ايران , SHABESTARI, ABBAS ARJMAND shahid beheshti university of medical sciences - Research Center for Gastroenterology Liver Diseases, تهران, ايران , ZALI, MOHAMMAD REZA shahid beheshti university of medical sciences - Research Center for Gastroenterology Liver Diseases, تهران, ايران
Abstract :
~ackground and Aims: Insulin-like growth factor-I (IGF-1) is a liver-derived humoral factor, which has important anabolic and metabolic actions. Low serum concentrations of IGF-1 have been reported in patients with chronic liver Idisease, especially cirrhosis and hepatocellular carcinoma and metastatic liver cancer. The aim of our study was to :evaluate any possible relationship between intensity of liver metastases on serum IGF-1 concentrations. IMethods: Serum IGF-1 were measured by ELIZA (III) in10 patients with uninodular or multinodular liver metastases land extension ~50% (group A) and 10 patients with multinodular or massive liver metastases and extension (GREATER THAN) 50% (group B) of liver size without liver failure. iResults: Serum IGF-1 concentration was significantly lower in the more sever metastatic group (group B) than the less sever metastatic group (group A) (121.40 (PLUS-MINUS) 52.08 vs. 210.30 (PLUS-MINUS) 42.59 ng/ml, respectively; P (LESS THAN)0.001). !conclusions: Our findings suggest that the states of serum IGF-1levels in patients with metastatic liver cancer may be l a helpful finding for determining the severity of metastasis to the liver.
Keywords :
IGF , 1 , Metastatic Liver Cancer , Computed Tomography
