Liver transplantation for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and isconsidered an aggressive tumor with mean survival estimated between 6 and 20 months. Hepatitis B andC are the most common etiologies. Pathological, laboratory and radiologic imaging all aid in diagnosisbut much controversy exists in the utilization of any given modality. Many treatment options exist formanagement of HCC, each has its own limitation. Liver transplantation offers the most reasonableexpectation for curative treatment while simultaneously removing the burden of the diseased liver. Still,advancements in the field have thus far not yet matched its potential, although new immunosuppressive andchemotherapy regimen may allow transplantation to push the envelope once again.