Regional hepatic therapies: an important component in the management of colorectal cancer liver metastases

The treatment of colorectal cancer liver metastases (CRLM) has evolved significantly in the last15 years. Currently, complete surgical resection remains the only potentially curative option; unfortunately,approximately 80% of patients with CRLM are not candidates for complete tumor resection. For patientswith unresectable CRLM the available treatment options were historically limited; however, the developmentof regional hepatic therapies (RHT) and improvement of systemic chemotherapeutic regimens have emergedas viable options to improve overall survival and quality of life for this group of patients. The selection,sequence and integration of interventions into a multi-modal approach is a complex and evolving discipline.In this article, the currently available RHT modalities for CRLM are presented as a guide to the options forclinical treatment decisions.