Author/Authors :
francis, taylor texas a m hsc - college of medicine, Temple, USA , graf, allyson texas a m hsc - central texas veteran’s health care system, Temple, USA , hodges, kyle texas a m hsc - 3scott white digestive disease research center, scott and white healthcare, Temple, USA , kennedy, lindsey texas a m hsc - scott white digestive disease research center, scott and white healthcare, Temple, USA , hargrove, laura texas a m hsc - scott white digestive disease research center, scott and white healthcare, Temple, USA , price, mattie texas a m hsc - 3scott white digestive disease research center, scott and white healthcare, Temple, usa , kearney, kate texas a m hsc - scott white digestive disease research center, scott and white healthcare, Temple, USA , francis, heather texas a m hsc - central texas veteran’s health care system, Temple, usa , francis, heather texas a m hsc - college of medicine, Temple, USA
Abstract :
The pancreas is a dynamic organ that performs a multitude of functions within the body.Diseases that target the pancreas, like pancreatitis and pancreatic cancer, are devastating and often fatal tothe suffering patient. Histamine and histamine receptors (H1-H4HRs) have been found to play a criticalrole in biliary diseases. Accordingly, the biliary tract and the pancreas share similarities with regards tomorphological, phenotypical and functional features and disease progression, studies related the role of H1-H4HRs in pancreatic diseases are important. In this review, we have highlighted the role that histamine,histidine decarboxylase (HDC), histamine receptors and mast cells (the main source of histamine in thebody) play during both pancreatitis and pancreatic cancer. The objective of the review is to demonstrate thathistamine and histamine signaling may be a potential therapeutic avenue towards treatment strategies forpancreatic diseases.
Keywords :
Histamine , pancreas , pancreatitis , pancreatic cancer
