Author/Authors :
cardinale, vincenzo university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , bragazzi, maria consiglia university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , carpino, guido university of rome “foro italico” - department of anatomical, histological, forensic medicine and orthopedics sciences, Rome, Italy , torrice, alessia university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , fraveto, alice university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , gentile, raffaele university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , pasqualino, vincenzo university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , melandro, fabio sapienza university of rome - department of general surgery and organ transplantation, Rome, Italy , aliberti, camilla sapienza university of rome - department of obstetrics and gynecology, Rome, Italy , bastianelli, carlo sapienza university of rome - department of obstetrics and gynecology, Rome, Italy , brunelli, roberto sapienza university of rome - department of obstetrics and gynecology, Rome, Italy , berloco, pasquale bartolomeo sapienza university of rome - department of general surgery and organ transplantation, Rome, Italy , gaudio, eugenio university of rome “foro italico” - department of anatomical, histological, forensic medicine and orthopedics sciences, Rome, Italy , alvaro, domenico university of rome “foro italico” - department of medico-surgical sciences and biotechnologies, Rome, Italy , alvaro, domenico eleonora lorillard spencer-cenci foundation, Rome, Italy
Abstract :
Cholangiocarcinoma (CCA) is a very heterogeneous cancer from any point of view, includingepidemiology, risk factors, morphology, pathology, molecular pathology, modalities of growth and clinicalfeatures. Given this heterogeneity, a uniform classification respecting the epidemiologic, pathologic andclinical needs is currently lacking. In this manuscript we discussed the different proposed classifications ofCCA in relation with recent advances in pathophysiology and biology of this cancer.
Keywords :
Cholangiocarcinoma (CCA) , biliary tree stem , progenitor cells , hepatic stem , progenitor cells , intrahepatic CCA , extra , hepatic CCA , cells of origin , biliary cancerogenesis
