• Title of article

    Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma

  • Author/Authors

    lee, ying-ying chinese university of hong kong - state key laboratory of digestive disease, hong kong, china , lee, ying-ying chinese university of hong kong - institute of digestive disease - department of medicine and therapeutics, Shenzhen, China , mok, myth t.s. chinese university of hong kong - school of biomedical sciences, Hong Kong, China , mok, myth t.s. chinese university of hong kong - shenzhen research institute, shenzhen, china , cheng, alfred sze-lok chinese university of hong kong - shenzhen research institute, shenzhen, china , cheng, alfred sze-lok chinese university of hong kong - state key laboratory of digestive disease, Hong Kong, China , cheng, alfred sze-lok chinese university of hong kong - school of biomedical sciences, hong kong, china

  • From page
    95
  • To page
    97
  • Abstract
    Error-prone integration of the hepatitis B virus X protein (HBx) into the hepatocellulargenome generates a multitude of mutants exerting diverse effects on the development and progression ofhepatocellular carcinoma (HCC). A recent study by Lai and colleagues revealed the disparate regulatoryactivity of clinically-predominant HBx mutants towards hypoxia-inducible factor-1α (HIF-1α), a centralregulator of tumor angiogenesis, proliferation, metastasis and differentiation. These findings have shedinsight into specific viral contribution of hypoxic response during hepatocarcinogenesis.
  • Keywords
    Hepatitis B virus X protein mutant (HBx mutant) , hepatocellular carcinoma (HCC) , hypoxia , induciblefactor , 1α (HIF , 1α)
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Record number

    2653943

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2653943