• Title of article

    Intestinal microbial metabolism of phosphatidylcholine: a novel insight in the cardiovascular risk scenario

  • Author/Authors

    ierardi, enzo university-hospital consorziale policlinico - gastroenterology unit, Bari, Italy , sorrentino, claudia university of bari - department of emergency and organ transplantation, section of gastroenterology, Bari, Italy , principi, mariabeatrice university of bari - department of emergency and organ transplantation, section of gastroenterology, Bari, Italy , giorgio, floriana university of bari - department of emergency and organ transplantation, section of gastroenterology, Bari, Italy , losurdo, giuseppe university of bari - department of emergency and organ transplantation, section of gastroenterology, Bari, Italy , di leo, alfredo university of bari - department of emergency and organ transplantation, section of gastroenterology, Bari, Italy

  • From page
    289
  • To page
    292
  • Abstract
    Intestinal microbiota is a “dynamic organ” influencing host metabolism, nutrition, physiology and immune system. Among its several interactions, the role of a phosphatidylcholine metabolite derived by gut flora activity, i.e., trimethylamine-N-oxide (TMAO), allows perceiving a novel insight in the cardiovascular risk scenario, being a strong predictor of this condition. Based on current reports, including the paper of Tang et al., we describe here: the possible role of intestinal microbiota in cardiovascular risk as well as potential interventions to reduce gut flora TMAO production by diet, probiotics and antibiotics. Finally, we highlight the possibility of evaluating, monitoring and modulating TMAO in order to use its serum levels as a marker of cardiovascular risk in the next future, when the need of controlled studies on large series will be satisfied
  • Keywords
    Intestinal microbiota , cardiovascular risk , trimethylamine , N , oxide (TMAO) , choline , probiotics , antibiotics
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Record number

    2654098

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2654098