Author/Authors :
brytska, nataliya state institution “zaycev v.t. institute of general and urgent surgery of national academy of medical sciences of ukraine” - department of hepatobiliary and pancreatic surgery, Ukraine , han, ho-seong seoul national university - seoul national university bundang hospital - department of general surgery, Seoul, South Korea , shehta, ahmed mansoura university - gastrointestinal surgical center - department of surgery, Mansoura, Egypt , yoon, yoo-seok seoul national university - seoul national university bundang hospital - department of general surgery, Seoul, South Korea , cho, jai young seoul national university - seoul national university bundang hospital - department of general surgery, Seoul, South Korea , choi, young rok seoul national university - seoul national university bundang hospital - department of general surgery, Seoul, South Korea
Abstract :
Background: The aim of this study was to evaluate the clinical and oncological outcomes after laparoscopicliver resection (LLR) in patients with hepatitis B and C virus-related hepatocellular carcinoma (HCC) withChild B or C cirrhosis.Methods: Between January 2004 and December 2013, LLR was performed in 232 patients with HCC. Ofthese, 141 patients also had pathologically proven cirrhosis. Sixteen patients with hepatitis B and C virusrelatedHCC with Child B or C cirrhosis were included in the study. Thirteen (81.3%) patients had Child Bdisease and three (18.8%) patients had Child C disease.Results: The median operation time was 215 min, the median estimated blood loss was 350 mL, and themedian hospital stay was eight days. Three patients (18.8%) experienced complications after surgery. Therewas no postoperative mortality or reoperation. The mean follow-up period was 51.6 months. HCC recurredin eight (50%) patients: seven intrahepatic recurrences and one extrahepatic recurrence. The treatments forrecurrence were laparoscopic reoperation in one (6.3%) patient, trans-catheter arterial chemo-embolization(TACE) in one (6.3%) patient, radiofrequency ablation (RFA) in one (6.3%) patient, and combined TACEand RFA in four (25%) patients. The five-year postoperative overall survival (OS) and disease-free survival(DFS) were 84.4% and 41.7%, respectively.Conclusions: This study demonstrates that LLR can be safely used in patients with hepatitis B and Cvirus-related HCC and Child B or C cirrhosis, with acceptable survival outcomes.
Keywords :
Cirrhosis , hepatocellular carcinoma (HCC) , laparoscopic liver resection (LLR) , survival
