Author/Authors :
wen, tianfu sichuan university - liver transplantation center, west china hospital - department of liver surgery, chengdu, china , jin, chen sichuan university - liver transplantation center, west china hospital - department of liver surgery, Chengdu, China , facciorusso, antonio university of foggia - department of medical and surgical sciences, Foggia, Italy , donadon, matteo humanitas university - humanitas clinical and research center - department of hepatobiliary general surgery, Milan, Italy , han, ho-seong seoul national university - seoul national university bundang hospital, college of medicine, Seoul, South Korea , mao, yilei chinese academy of medical sciences - peking union medical college hospital, peking union medical college - department of liver surgery, Beijing, China , dai, chaoliu china medical university - shengjing hospital - department of hepatobiliary and splenic surgery, Shenyang, China , cheng, shuqun second military medical university - eastern hepatobiliary surgery hospital - department of hepatic surgery vi, Shanghai, China , zhang, bixiang huazhong university of science and technology - hepatic surgery center, tongji hospital, Wuhan, China , peng, baogang first affiliated hospital of sun yat-sen university - department of liver surgery, Guangzhou, China , du, shunda chinese academy of medical sciences - peking union medical college hospital, peking union medical college - department of liver surgery, Beijing, China , jia, changjun china medical university - shengjing hospital - department of hepatobiliary and splenic surgery, Shenyang, China , xu, feng china medical university - shengjing hospital - department of hepatobiliary and splenic surgery, Shenyang, China , shi, jie second military medical university - eastern hepatobiliary surgery hospital - department of hepatic surgery vi, Shanghai, China , sun, juxian second military medical university - eastern hepatobiliary surgery hospital - department of hepatic surgery vi, Shanghai, China , zhu, peng huazhong university of science and technology - hepatic surgery center, tongji hospital, Wuhan, China , nara, satoshi national cancer center hospital - hepatobiliary and pancreatic surgery division, Tokyo, Japan , millis, j. michael university of chicago - department of surgery, Chicago, USA
Abstract :
Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40–70% patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients’ prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength of recommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.
