• Title of article

    PENGAMATAN VISUAL TAHAP-TAHAP PEMBENTUKAN KRISTAL SISTEM EUTEKTIKUM ASETAMINOFEN -PSEUDOEFEDRIN HIDROKLORIDA

  • Author/Authors

    Nugrahani, Ilma Sekolah Farmasi Institut Teknologi Bandung, Indonesia , Asyarie, Sukmadjaja Sekolah Farmasi - Institut Teknologi Bandung, Indonesia , Soewandhi, Sundani Nurono Sekolah Farmasi - Institut Teknologi Bandung, Indonesia , Ibrahim, Slamet Sekolah Farmasi - Institut Teknologi Bandung, Indonesia

  • From page
    17
  • To page
    23
  • Abstract
    The aim of this research was to observ the recrystallization process of two component,acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles.The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
  • Keywords
    acetaminophen , crystals habit , ethanol , pseudoephedrine HCl
  • Journal title
    Pharmaceutical Sciences an‎d Research
  • Journal title
    Pharmaceutical Sciences an‎d Research
  • Record number

    2654762

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2654762