The effect of chronic iron drug compound exposure on some biochemical values in ewes suffer from iron deficiency

The study was conducted to evaluate the effects of chronic iron toxicity on some biochemical parameters. Twenty Iraqi local breed ewes at age (2-4) year, clinically pregnant have different class of iron deficiency at the period from 25/10/2012 to 31/1/2013, animal divided into two groups, treated group treated with 10 mg/ kg of body weight iron dextran every week for 12 weeks, control group leave on its feed only. All animals monitored clinically during the study: Serum biochemical tests: total protein, albumin, globulin, cholesterol, alanine aminotransferase, serum iron, total iron binding capacity, Unbound iron binding capacity, transferrin saturation at the weeks (zero, 2, 4, 6, 8, 10, 12, 14) during the period of iron dextran injections. Serum biochemical tests result showed: that total protein of treated group showed significant increases (p 0.05) reached 6.8g/dl at the weeks 2, and then a gradual decrease reached 4.3 at the weeks 14. While, ewes of control group increased reach 6.31 g/dl at weeks 2 and remained unchanged to end of study at the weeks 14. Albumin and globulin of treated group showed significant increase (p 0.05) at the weeks 2, and then gradual decrease to reached 2.4g/dl, 1.9g/dl respectively. While, ewes of control group showed a variable result which ranged (1.6-3.3) g/dl for albumin and (1-4.1) g/dl. Alanine aminotransferase of treated group showed a significant decrease reached 34.8 U/L at the weeks 12, and then a significant increase reached 43 U/L at the weeks 14. While, ewes of control group showed no significant difference and ranged (36-42 U/L). Cholesterol of treated group showed a gradual increase reached 110 mg/dl at the weeks 6 then gradual decrease to reached 19mg/dl at the weeks 14. While, control group showed significant increase at the weeks 6 then return to it is level (44-56) mg/dl. Glucose of treated group showed a significant increase reached 75.8 mg/dl at the weeks 10. While, the ewes of control group showed significant increase at the weeks 14 only. Serum iron of treated group showed gradual increase reach the peak 54 μmol / L at the weeks 4 then gradual decrease to reached 22 μmol/ L at the weeks 14. While, ewes of the control group showed gradual increase at weeks 2 reach 30 μmol / L and remained unchanged after that. Total iron binding capacity of treated group showed a gradual increase reached the peak 246 μmol/ L at the weeks 8. On other hand control group showed variable result range (47-97) μmol/L, depend on the normal range (42.9-74.1). Unbound iron binding capacity of treated group showed a gradual increase reached 140 μmol/ L at the weeks 10. On other hand ewes of control group showed variable result range (22-60) μmol/L. depending on the normal range (16.9-46.6) Transferrin saturation of treated group showed a gradual increase reach 45.2% at the weeks 6 then gradual decrease reached 20% at the weeks 10. On other hand control group showed variable result rang (32-59)%. According to these result it is concluded that: 10 mg/kg B.W iron dextran weekly for one month considers a good treatment for anemia but if continues treating could cause accumulation in the body and interfere with the body metabolisms.