Title of article :
ENHANCED CANCER CELL (HELA) KILLING EFFICACY OF MIXED ΑLPHA AND GAMMA IRON OXIDE SUPERPARAMAGNETIC NANOPARTICLES UNDER COMBINED AC (ALTERNATING CURRENT) MAGNETIC-FIELD AND PHOTOEXCITATION
Author/Authors :
ISLAM, MD. SHARIFUL Kagoshima University - Graduate School of Science and Engineering - Department of Chemistry and Bioscience, Japan , KUSUMOTO, YOSHIHUMI Kagoshima University - Graduate School of Science and Engineering - Department of Chemistry and Bioscience, Japan , AL-MAMUN, MD. ABDULLA Kagoshima University - Graduate School of Science and Engineering - Department of Chemistry and Bioscience, Japan , HORIE, YUJI Kagoshima University - Graduate School of Science and Engineering - Department of Electrical and Electronics Engineering, Japan
Abstract :
We synthesized mixed α and γ-Fe_2O_3 nanoparticles and investigated their toxic effects against HeLa cells under induced AC (alternating current) magnetic-fields and photoexcited conditions at room temperature. The findings revealed that the cellkilling percentage was increased with increasing dose for all types of treatments. Finally, 99% cancer cells were destructed at 1.2 mL dose when exposed to combined AC magnetic-field and photoexcited conditions (T_3) whereas 89 and 83 % of HeLa cells were killed under only AC magnetic-field induced (T_1) or only photoexcited (T_2) condition at the same dose.
Keywords :
cancer , hyperthermia , iron oxide nanoparticles , heat dissipation, cytotoxicity , HeLa cell
Journal title :
IIUM Engineering Journal
Journal title :
IIUM Engineering Journal
