Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

The present study was designed to investigate the adverse effects of Cypermethrin (CYP) intoxication on the liver, kidney, brain and heart and the probable alleviating capability of vitamin E and Selenium combination (VE/Se) against such effects. Twenty-four male albino rats were divided randomly into 4 equal groups (6 rats each), CYP-treated rats received CYP (4.67 mg/kg bwt equals 1/10 LD_50) orally once daily, CYP +VE/Se-treated rats were injected subcutaneously with 0.2 ml/kg bwt Viteselen®15 twice weekly with concurrent daily administration of CYP once daily, VE/Se- treated rats and control group. After 60 days treatment all rats were euthanized. CYP induced significant increase in serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), urea, creatinine and malondialdhyde (MDA) levels and a significant reduction in reduced glutathione (GSH) level. Also, CYP revealed marked degenerative and necrotic alterations in liver, kidneys, brain and heart. Conversely, treatment with VE/Se combination improved CYP-induced oxidative damage and the histopathological alterations of these organs. Results indicated that CYP exerts significant harmful effects. And the concurrent administration of VE/Se partly reduced these detrimental effects.