Relation of insulin-like growth factor to skin ageing

Background: Insulin-like growth factor-1 (IGF-1) can influence fibroblast functioning, with inhibition of collagenases and induction of collagen expression. IGF-1 may have a role in delaying the accumulation of skin wrinkles. Objective: To evaluate the relation between serum IGF-1 levels and facial ageing. Patients and methods: This study included 63 healthy volunteers. Facial ageing assessment and descriptive scale for evaluation of skin photodamage were performed for all patients. The sera levels of IGF-1 and insulin-like growth factor binding protein-3 were estimated using an enzyme-linked immunosorbent assay technique. Results: Serum levels of IGF-1 decreased with increasing facial ageing stage and photoaging grading. Serum level of IGF-1 was significantly higher in patients with negative history of diabetes mellitus, hypertension, and excessive sun exposure. Conclusion: Serum level of IGF-1 decreased with increasing chronological ageing and with increasing facial ageing and photoaging. IGF-1 may be considered as an important factor in prevention of facial ageing.