Author/Authors :
mostafa, wedad z. cairo university - faculty of medicine - department of dermatology, Giza, Egypt , assaf, magda i. zagazig university - faculty of medicine - department of pathology, Zagazig, Egypt , abdel-halim, mona r.e. cairo university - faculty of medicine - department of dermatology, dermatopathology unit, Giza, Egypt , amin, iman m. cairo university - faculty of medicine - department of dermatology, Giza, Egypt , el-tobshy, seham a. cairo university - students hospital - dermatology department, Cairo, Egypt
Abstract :
Background Involvement of eccrine sweat glands in adverse cutaneous drug reactions (ACDRs) has not received sufficient interest. Objective To examine histopathological changes in eccrine sweat glands in ACDRs. Patients and methods Forty ACDR cases were recruited. Lesional and nonlesional biopsies underwent thorough histopathological evaluation of the eccrine apparatus. Results The eccrine apparatus was involved in 97.5% of lesional skin biopsies, secretory coils most frequently, and in 42.1% of apparently normal skin biopsies, and the difference was statistically significant (P 0.05). The most frequently encountered changes in lesional skin included acrosyringial necrosis, intraductal inflammatory cell infiltrate, and hydropic degeneration of the secretory coils. Conclusion The invariable involvement of the eccrine sweat apparatus in ACDRs appears to be largely secondary to different mediators of the inflammatory process rather than events primarily and directly caused by the inciting drugs
