Title of article :
Anti-Oxidant Protective Effects of Cassia Alata in Rats Exposed to Carbon Tetrachloride
Author/Authors :
WEGWU, M.O. University of Port Harcourt - Department of Biochemistry, Nigeria , AYALOGU, E.O. University of Port Harcourt - Department of Biochemistry, Nigeria , SULE, O.J. Niger Delta University - Departments of Medical Biochemistry, Nigeria
Abstract :
The protective activity of Cassia alata against carbon tetrachloride (CCl4) – induced hepatotoxicity in rats was assessed. Crude extracts of petals of the plant in 0.5% ethanol were administered by intubation for 14 days prior to injection of 0.5ml Kg^-1 CCl4 into the rats. Serum aspartate aminotransferase and alanine aminotransferase levels, 18 hours after CCl4 administration, decreased significantly (P ≤ 0.05) in rats treated with the extracts than in CCl4 – treated rats only. These findings suggest that Cassia alata may be protective against hepatotoxin-induced liver damage in rats.
Keywords :
Anti-Oxidant Protective , Cassia Alata , Rats Exposed , Carbon Tetrachloride
Journal title :
Journal of Applied Sciences and Environmental Management
Journal title :
Journal of Applied Sciences and Environmental Management
