Author/Authors :
Ghoreishi, Mohammad isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Attarzadeh, Hossein isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Zandi, Alireza isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Moini, Heidar-Ali isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Tavakoli, Mehdi isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Fesharaki, Hamid isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران , Nasrollahi, Kobra isfahan university of medical sciences - Persian Eye Clinic, اصفهان, ايران
Abstract :
Purpose: To report the efficacy, safety, predictability and complications of photorefractivekeratectomy (PRK) with intraoperative application of mitomycin-C (MMC).Methods: This historical cohort study was performed on 1,250 eyes of 625 patients whounderwent PRK using the Technolas 217 excimer laser machine by a single surgeon withintraoperative use of MMC 0.02% up to 2 minutes, depending on depth of ablation. Acomplete ophthalmologic examination was performed which included refraction,uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and slitlampbiomicroscopy. Outcomes were analyzed after one year of follow-up.Results: The mean preoperative spherical equivalent refractive error was -4.85±2.27(range, -2.50 to -13.5) diopters (D). Mean depth of ablation was 89±22 microns and meantime to reepithelialization was 4.5±1.7 days. At final follow-up, UCVA of 20/20 and20/40 or more was achieved in 92.1% and 99.2% of eyes, respectively. One year postoperatively,69.4% and 91% of eyes were within ±0.50 D and ±1.00 D of emmetropia.Overall, 62 eyes (4.9%) developed one or two lines of decrease in BCVA, and 50 eyes(4%) developed corneal haze which was grade 1 or 2 in most cases; grade 3 and 4corneal haze was found in 4 and 2 eyes, respectively. No other adverse event was notedduring the study period.Conclusion: PRK with intraoperative application of MMC provides excellent visualoutcomes with acceptable safety and predictability, and entails minimal side effects.
