Author/Authors :
Nikzamir, Abdolrahim Faculty of Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Rezaei-Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Razzaghi, Mohhamadreza Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Rezaei Tavirani, Sina Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Hamzeloo-Moghadam, Maryam Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Esmaeili, Somayeh Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Hatami, Behzad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Ahmadzadeh, Alireza Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences - Tehran, Iran
Abstract :
Evaluation of deregulated genes after long-term consuming of omeprazole via network analysis.
Background: Proton pump inhibitors (PPIs) are used to inhibit gastric high rate of acid secretion in patients. Omeprazole as a PPI is a
common drug in this regard. Evaluation of long-term consumption of omeprazole is studied in the present study via its effects on the
gene expression of “human coronary artery endothelial cells”.
Methods: Net effect of the presence of omeprazole on gene expression profiles of “human coronary artery endothelial cells” was
evaluated through data from gene expression omnibus (GEO). Results of protein-protein interaction (PPI) network analysis were
assessed via biological process examination to find the critical deregulated genes after long-term consumption of omeprazole.
Results: “Negative regulation of muscle cell apoptotic process”, “negative regulation of DNA binding”, “telencephalon cell
migration”, “forebrain cell migration” “response to cadmium ion”, “cell-cell recognition”, “positive regulation of protein targeting to
mitochondrion”, and “central nervous system neuron development” were the clusters of biological processes that were associated to
the long -term presence of omeprazole. The final critical deregulated genes were JAK2, PTK2, and NRG1.
Conclusion: It can be concluded that cell cycle, proliferation, and apoptosis and several essential biological processes are affected and
nervous system is a possible target related to the long-term consumption of omeprazole.
