Synthesis of C- glycoside analogs containing thiouracil derivatives and evaluated as antibacterial, antifungal and antioxidant activities

This work focused on the synthesis of Cglycoside that contained thiouracil unite, which were synthesized from glucon-2-carbothioate thiouracil derivatives [C1-C4] via reaction of gluconic acid, thionyl chloride, and thiouracil derivatives in a one-pot reaction in the presence of triethylamine as a catalyst. Furthermore, we performed synthesis of 2-(glucofuranose) thiouracil derivatives [C5, C6] via condensation reaction of D glucurone, ethyl cyanoacetate, and thiourea or phenyl thiourea in presence of potassium carbonate, and studying the possibility for their application as antifungal, antibacterial, and antioxidant.