Variation of Adiponectin Levels in Normal and Obese subjects: Possible Correlation with Lipid Profiles

Data available suggests that Adiponec-tin, an adipocyte.derived peptide, is associated with adiposity and could ef- fect the regulation of glucose and lipid metabolism in humans. The aim of this study was to evaluate the association between serum adiponectin concentrations and anthro-pometric indices and lipid profiles among Ira-nian women with different grades of obesity. Materials and Methods: In this analytical de-scriptive study of 157 non-diabetic women (33 normal weight, BMI 25 kg/m2 and 124 over- weight and obese, BMI. 25kg/m2), serum adipo-nectin and leptin levels were measured using an enzyme-linked immunoassay. Fasting glucose and lipid profile levels determined by the glucose oxidize and enzymatic methods, respectively. Results: Mean serum adiponectin concentra tionsignificantly decreased with obesity (p 0.05). Although adiponectin showed a significant negative correlation with BMI (r=-0.321), it was cor- related with serum leptin (r=-0.139), glucose (r=0.259), LDL-C (r=-0.125), TGs (r=-0.210) levels, TSF (r=-0.145), WHR (r=-0.159), and positively with serum HDL-C concentration (r=0.218) in all subjects (p 0.05). Results of multiple regression analyses showed that adiponectin as a depen- dent variable had a significant correlation with BMI (s=-0.605, P=0.017), waist circumference (s=0.624,p=0.029),WHR(s=-0.251, p=0.048), frame (s=0.260, p=0.018), TC/HDL-C ratio ( s=-0.1.309, p=0.040) and LDL/HDL ratio (ß=-1.343, p=0.007) and changes in waist size had a significant effect on serum adiponectin levels. Conclusion: Our results suggested that adiponectin had an inverse correlation with adiposity indices and unfavorable lipid profiles, and that variation of waist circumference mostly affected Iranian women.