Author/Authors :
Payandeh, Mehrdad kermanshah university of medical sciences - Medical Biology Research Center, ايران , Yousefi, Hoshang High Institue for Research and Education in Transfusion Medicine - Biood Transfusion Research Center, ايران , Zare, Mohammad Erfan kermanshah university of medical sciences - Medical Biology Research Center - Student Research Committee, ايران , Nasir Kansestani, Atefeh kermanshah university of medical sciences - Medical Biology Research Center - Student Research Committee, ايران , Rahimi, Zohreh kermanshah university of medical sciences - School of Medicine, Medical Biology Research Center - Department of Biochemistry, ايران , Pourmand, Dariush kermanshah university of medical sciences - Paramedicine Faculty - Department of Medical Lab Science, ايران , Hashemian, Amir Hossein kermanshah university of medical sciences - Faculty of Public Health - Department of Biostatistics, ايران , Aeinfar, Mahmood islamic azad university - Faculty of Technology - Student Research Committee, Electronic Department, ايران , Aeinfar, Mehrnoush kermanshah university of medical sciences - Medical Biology Research Center, ايران , Shaveisi Zadeh, Farhad shahid beheshti university of medical sciences - Faculty of Medicine - Departments of Medical Genetics, تهران, ايران
Abstract :
Introduction: The main inhibitors of coagulation pathway are antithrombin (AT), protein C and protein S. These inhibitors are necessary to prevent thromboembolism. Hereditary deficiency of inhibitors is the main cause of alteration in balance between the anti-clotting and the formation of thrombin. Patients with this abnormality are susceptible to venous thromboembolism (VTE). Two major clinical manifestation of VTE are deep vein thrombosis (DVT) and pulmonary embolism (PE). The aim of present study was to investigate the frequency of coagulation inhibitor proteins and resistance to activated protein C (APC-R) in DVT patients from Kermanshah province of Iran with Kurdish ethic background. Materials and methods: We investigated all patients with thrombophilia who referred to Iranian Blood Transfusion Organization from May 2011 to March 2012. The levels of protein C, protein S and antithrombin were measured using STAGO kits, France (Diagnostica Stago) and the APC-R level was detected using Pefakit® kit. Results: After excluding patients with confounding factors, 54 patients were remained. Our results showed that acquired risk factors are the most common causes of DVT in the present study. In our study protein C deficiency was found to be the most hereditary risk factor followed in frequency by APC-R. Also, in 16 patients (29.6%) there were combined hereditary risk factors with deficiency in 2 or 3 factors.
Keywords :
Deep Vein Thrombosis , Coagulation , Coagulation Risk Factors , Hereditary
