Title of article :
Hypermethylation Status of Promoter is an Epigenetic Change in Lymphoied Malignancies
Author/Authors :
Farshdousti Hagh, Majid tabriz university of medical sciences - Faculty of Medicine, Hematology and Oncology Research Center - Division of Laboratory Hematology and Blood Banking, ايران , Saki, Najmaldin ahvaz jundishapur university of medical sciences - Thalassemia and Hemoglobinopathy Research Center, اهواز, ايران , Khamisipour, Gholamreza bushehr university of medical sciences, ايران
Abstract :
Alteration in methylation pattern of promoters is associated with tumorigenic events,(1, 2) and differentiation control,(3, 4) in several types of cells in humans. Specific hypermethylation in promoter region of some genes exist in different types of neoplastic cells.(5) DNA methylation indicates to the addition of a methyl moiety to the cytosine in a CpG dinucleotide. CpG dinucleotides tend to gather closely together in CpG islands, and are usually located in promoter region of genes.(6)
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
Journal title :
International Journal of Hematology-Oncology and Stem Cell Research (IJHOSCR)
