Estimation of Xanthine oxidase activity, related with Nitric oxide (NO) and lipid profile in serum of patients with atherosclerotic diseases

This research outlines the study of xanthine oxidase activity (XO) , nitric oxide (NO) ) and lipid profile with an atherosclerotic disease(angina and cerebral thrombus) . The study covers 46 atherosclerotic disease patients (26 males , 20 females ) and 29 healthy subjects (control group) .The two groups contain males and females whose ages ranged between (38-65) years .The parameters ; Xanthine oxidase activity (XO) , Nitric oxide (NO) and lipid profile were investigated . The results of these subjects studied (patient and control group) have significant increase in the activity of Xantine oxidase and concentration of Nitric oxide, triglyceride, cholesterol, low density lipoprotein and very low density lipoprotein in the serum of atherosclerotic diseases (angina and cerebral thrombus) compared to control groups. The increase amounts are to 360%, 240%, 2.3%, 23.5%, 54.8% and 2.3% respectively as compared to control groups. The result indicates a significant decrease in the concentration of high density lipoprotein (HDL). The decrease amounts to 27% as compared to control groups. On the other hand, the results of these subjects studied show no significant different parameters in sex .